Issues

Cytomatrix, a new procedure to enhance the diagnostic usefulness of fine needle aspirates

ABSTRACT
Fine-needle aspirates are still the basis of cytodiagnosis for neoformation of visceral organs; nevertheless, there is an increasing role for ancillary testing. Specimens obtained are not always optimal, and prevent a conclusive diagnosis when other complementary tests are needed to reach this goal. This study aims at evaluating a novel technology called “CytoMatrix” to entrap the cytology collections in a synthetic matrix that can be processed as a histology specimen, allowing to perform immunohistochemical and molecular biology analyses. Cytological material from twenty-five fine-needle aspirates were collected from different anatomical areas and from benign and malignant lesions. The collected aspirated material was transferred onto CytoMatrix, and processed for histology, immunohistochemistry and FISH analyses. In all the cases processed with the synthetic matrix, final diagnosis was reached. Nevertheless, immunohistochemistry and FISH were successfully performed on the malignant neoformations analyzed and the data produced allowed to precisely define the phenotype of the cancer. The results show that this synthetic matrix allows an easy and fast analysis of morphological and molecular characteristics of fine-needle aspirate material from various lesions.

IMPACT STATEMENT
Definition of an original synthetic matrix that allows an easy and fast analysis of morphological, immunohistochemical and molecular characteristics of fine needle aspirate material from various malignancies.

Table of Content: Vol. 1 (No. 3) 2021 September

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