This report summarizes the scientific presentations from the 33rd Annual Meeting of the Society for Basic Urological Research (SBUR), held from November 13 to 16, 2025, in Orlando, Florida, USA. This year’s meeting gathered researchers, clinicians, and trainees from the United States and other countries to discuss new discoveries that are shaping the future of urologic research. Sessions showcased advances from basic molecular mechanisms to clinical applications, focusing on prostate cancer biology, treatment resistance, metabolic weaknesses, and new treatment strategies. The presentations highlighted the need to combine basic research with various clinical approaches to improve patient outcomes and further the field of urologic oncology.