Hedgehog signaling pathways in multiple myeloma

Multiple myeloma (MM) is a hematological disease characterized by the uncontrolled proliferation of bone marrow malignant plasma cells. Localization and survival of malignant cells relies on bone marrow niche, in turn determined by the interaction between MM cells and mesenchymal stromal cells (MSCs). Several reports suggest that Hedgehog (Hh) pathway plays an outstanding role in tumor microenvironment maintenance. Hh signaling orchestrates the transformation of the myeloma bone marrow microenvironment supporting the proliferation of malignant plasma cells by affecting NF-kB signaling. To date, different clinical approaches are currently undergoing to evaluate the role of Hh modulators as efficient MM therapy. In this review article, we discuss the recent advances in the understanding of Hh signaling pathway in MM microenvironment.

Several reports investigated the role of Hedgehog signaling in multiple myeloma progression. In this review we discuss the recent advancements in this field, also considering the new drugs currently in clinical trial.


Table of Content: Vol. 2 (No. 2) 2022 June

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