ABSTRACT
This study aimed to assess the incidence and patient characteristics of Endometrial cancer (EC) in an Italian Cancer Registry and identify those factors that may have an impact on the diagnosis and prognosis.
The three outcomes investigated were disease-free survival (DFS), recurrence, and overall survival (OS), by age and stage in the Reggio Emilia province from 2013 to 2015.
234 cases were registered: over 90% were over 50 years old, 69% were classified as stage I, nearly 86% had surgery, and 14.5% received chemotherapy. There were 21 recurrences, 10 were in stage III, 8 in stage I, and only 2 in stage II. Stage III presents a 53% recurrence rate in the first year, decreasing however in the following years.
DFS length increased at 1 and 3 years after diagnosis, rising from 60% to close to 86% for stage II and from more than 23% to 57% for stage III. The 5-year OS rate was about 79%, with values of 96.1%, 59.2%, 44%, and 17.3 % for stages I, II, III, and IV respectively a 100% 89.4% and 64.9% for age <59, 50-65 and 65+, respectively. Multivariate analysis confirms an increased stage-related risk for both DFS and OS, but the age-related risk disappears.
Even though most EC are stage I, there remains an increased risk of recurrence for stage III tumors; age does not seem to represent an important determinant, confirming the importance of good ab initio management of patients.

IMPACT STATEMENT
This population-based study, based on cancer registry data, shows that most endometrial cancers are stage I, but the risk of recurrence remains high for stage III cancers.