Issues

Applications of electroporation in human and veterinary oncology

ABSTRACT
Electroporation (EP) is a methodology that favors the transport of different molecules in various in vitro and in vivo settings, by the application of electric pulses displaying suitable amplitude and waveforms. EP has been widely implemented in veterinary oncology and one of the most well recognized applications is electrochemotherapy (ECT), that is presently adopted as a first-line cure for numerous neoplastic pathologies.
Other applications in veterinary oncology include irreversible electroporation and EP based cancer vaccines. In human oncology, EP is still mostly restricted to the cure of cutaneous tumors, and to palliation of cutaneous and visceral metastases of malignant tumors.
This review article summarizes the state of the art of EP in veterinary and human oncology, reporting the most important outcomes gotten to date.

IMPACT STATEMENT
The use of electric pulses to facilitate the transport of anticancer molecules in in vitro and in vivo models is an extensively acknowledged procedure, that is identified as electroporation (EP). This article reviews the state of art of distinct EP applications, such as electrochemotherapy (ECT), irreversible electroporation and EP based cancer vaccines in veterinary and human oncology.

 

Table of Content: Vol. 4 (No. 4) 2024 December

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